liveonearth: (moon)
Not sure what to make of this:
http://altering-perspectives.com/2014/02/dna-analysis-elongated-skull-released-results-incredible.html

Sounds like the creatures who had elongated hominid skulls found in Peru were genetically quite different from homo sapiens.
liveonearth: (Default)
http://www.medscape.com/viewarticle/735066?src=mp&spon=22

Vitamin D deficiency occurs more frequently in patients with primary hyperparathyroidism (PHPT) compared with the general population, and is usually associated with an aggravated form of the disease. Current guidelines recommend measurement of serum levels of 25-hydroxy vitamin D (25-OHD) in all patients with PHPT, and their repletion if the levels are less than 50 mmol/L (20 ng/mL). Limited data suggest that vitamin D treatment is generally safe in subjects with mild PHPT and coexisting vitamin D deficiency. Adverse effects include hypercalcuria and, less commonly, exacerbation of hypercalcemia. Well-designed trials are needed to evaluate the safety of vitamin D replacement therapy in a wide spectrum of patients with concomitant PHPT and vitamin D deficiency. These trials should address the impact of such therapy on the complications and course of PHPT.
liveonearth: (Default)
congenital = present at birth
hereditary = inherited
familial = runs in family
genetic = caused by gene

reduced penetrance often at work in dominant diseases: genotype does not "penetrate" to phenotype

notes on osteogenesis imperfecta, neurofibromatosis, achondroplasia, marfan syndrome, polycystic kidney disease )

Acromegaly

Dec. 16th, 2010 10:36 pm
liveonearth: (Default)
What are the face, skull and foot changes seen with acromegaly?
more )
liveonearth: (Default)
Well so we already knew that drugs that increase serotonin levels decrease bone density over time. Medscape's new report says that osteoporosis is associated not just with SSRIs, but with benzos and some mood stabilizers other than lithium. Tricyclic antidepressants are protective for bones, but they have other gnarly side effects.

They've also found that mental disorders themselves have significant bone correlations. Dementia, schizophrenia and alcohol dependence are associated with reduced bone density. Depression is associated with less osteoporosis---which makes sense if you think that a lot of depression is due to low serotonin levels. Bipolar disorder and drugs other than alcohol were not found to have any correlation with osteoporosis.

Aside: FDA has released new warning that Tramadol (an opioid) increases suicide risk.
liveonearth: (Default)
MIDTERM IS WEEK 5
bring fasting info page for Thea
don't mobilize hands/wrists in case of arthritis until you have a firm dx
know the disease process
don't do grade 3+ if inflamed
notes on Frangos' lab class 2-5pm )
liveonearth: (Default)
(whoda thunkit)

Beer Bones and Hops
Jacob Schor
March 2010

The online version of this article contains abstracts of all papers referenced and may be found at:
http://denvernaturopathic.com/beerandbones.htm
Text here: great article from Denver Naturopathic on effects of Humulus lupulus and more. )
liveonearth: (Default)
Fosamax works great for building bone density in the short term, but is it good for the long term?

Excess bone deposition + no bone resorption --> heavy bones that spontaneously fracture in strange places.

Science suggests patients on fosamax should take a break from the meds at 5 years.
Jacob Schor says in his practice he's suggesting a break after 3 years, to be conservative.
Bisphosphonates formerly used to soften water in orange grove irrigation systems.
the latest from Denver Naturopathic )
liveonearth: (Default)
widespread assumption: serotonin is benign substance that makes people happier
widely accepted that both l-tryp and 5HTP ameliorate depression w/o SEs
but serotonin DOES have SEs
research suggests serotonin hinders formation of new bone-->net loss
supplements increasing serotonin, 5HTP, melatonin, or L-tryptophan detrimental to bone???

Literature Review (September 2009)
Serotonin Production And Bone Health
By Jacob Schor, ND, FABNO
from: http://www.naturalmedicinejournal.com/pdf/liit_rev_seratonin.pdf
notes )

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