liveonearth | Entries tagged with bones

Not sure what to make of this:
http://altering-perspectives.com/2014/02/dna-analysis-elongated-skull-released-results-incredible.html

Sounds like the creatures who had elongated hominid skulls found in Peru were genetically quite different from homo sapiens.

( notes )

( notes from Stansbury's week 10 6/12/2009 lecture, there will be a week 11 lecture as well )

sites for assessing micronutrient contents of food
www.nal.usda.gov/fnic/foodcomp/search/
www.nutritiondata.com
( our last nutrition I lecture with professor Gerber, moved forward from same date 2009, already got thyroid, anemia bits )

( combined notes from diagnostic imaging (Stecher), nutrition (Marz 2010), Wilson/Brinson shift 2011, blk bk page completed )

1000 on Ca+ only-->6 more MI's or strokes and 3 less fractures
( data from the Women's Health Initiative added to the meta-analysis of cardiovascular risks associated with calcium supplements )

( rudimentary notes: for boards just remember where diuretics work on tubules, big picture renal fx )

http://www.medscape.com/viewarticle/735066?src=mp&spon=22

Vitamin D deficiency occurs more frequently in patients with primary hyperparathyroidism (PHPT) compared with the general population, and is usually associated with an aggravated form of the disease. Current guidelines recommend measurement of serum levels of 25-hydroxy vitamin D (25-OHD) in all patients with PHPT, and their repletion if the levels are less than 50 mmol/L (20 ng/mL). Limited data suggest that vitamin D treatment is generally safe in subjects with mild PHPT and coexisting vitamin D deficiency. Adverse effects include hypercalcuria and, less commonly, exacerbation of hypercalcemia. Well-designed trials are needed to evaluate the safety of vitamin D replacement therapy in a wide spectrum of patients with concomitant PHPT and vitamin D deficiency. These trials should address the impact of such therapy on the complications and course of PHPT.

congenital = present at birth
hereditary = inherited
familial = runs in family
genetic = caused by gene

reduced penetrance often at work in dominant diseases: genotype does not "penetrate" to phenotype

( notes on osteogenesis imperfecta, neurofibromatosis, achondroplasia, marfan syndrome, polycystic kidney disease )

What are the face, skull and foot changes seen with acromegaly?
( more )

( notes )

( from housemate's pathology notes )

( notes on calcium from Gerber/nutrition I lecture )

Well so we already knew that drugs that increase serotonin levels decrease bone density over time. Medscape's new report says that osteoporosis is associated not just with SSRIs, but with benzos and some mood stabilizers other than lithium. Tricyclic antidepressants are protective for bones, but they have other gnarly side effects.

They've also found that mental disorders themselves have significant bone correlations. Dementia, schizophrenia and alcohol dependence are associated with reduced bone density. Depression is associated with less osteoporosis---which makes sense if you think that a lot of depression is due to low serotonin levels. Bipolar disorder and drugs other than alcohol were not found to have any correlation with osteoporosis.

Aside: FDA has released new warning that Tramadol (an opioid) increases suicide risk.

MIDTERM IS WEEK 5
bring fasting info page for Thea
don't mobilize hands/wrists in case of arthritis until you have a firm dx
know the disease process
don't do grade 3+ if inflamed
( notes on Frangos' lab class 2-5pm )

(whoda thunkit)

Beer Bones and Hops
Jacob Schor
March 2010

The online version of this article contains abstracts of all papers referenced and may be found at:
http://denvernaturopathic.com/beerandbones.htm
( Text here: great article from Denver Naturopathic on effects of Humulus lupulus and more. )

Fosamax works great for building bone density in the short term, but is it good for the long term?

Excess bone deposition + no bone resorption --> heavy bones that spontaneously fracture in strange places.

Science suggests patients on fosamax should take a break from the meds at 5 years.
Jacob Schor says in his practice he's suggesting a break after 3 years, to be conservative.
Bisphosphonates formerly used to soften water in orange grove irrigation systems.
( the latest from Denver Naturopathic )

widespread assumption: serotonin is benign substance that makes people happier
widely accepted that both l-tryp and 5HTP ameliorate depression w/o SEs
but serotonin DOES have SEs
research suggests serotonin hinders formation of new bone-->net loss
supplements increasing serotonin, 5HTP, melatonin, or L-tryptophan detrimental to bone???

Literature Review (September 2009)
Serotonin Production And Bone Health
By Jacob Schor, ND, FABNO
from: http://www.naturalmedicinejournal.com/pdf/liit_rev_seratonin.pdf
( notes )

( On the biochemistry of collagen, how wounds heal, and some pathologies including Ehlers-Danlos syndrome, Osteogenesis Imperfecta, Systemic Sclerosis, Keloid scarring, and also Marfan's for comparison, even though Marfan's is a fibrillin deficency not collagen. )

( summary of Goljan's lecture )

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another member in the Pre-Human Family?
Environmental Medicine (week 6 & 7): Heavy Metals
Herbs: Menopause, Hormone Replacemnet
Mineral Nutrition: Copper, Iodine, Zinc, Manganese
Conditions: Osteoporosis
New Data on Calcium and Vitamin D Supplementation
Renal Tubular Acidosis
Vitamin D deficiency in pts with Hyperparathyroid
Genetics (week 5): Inheritance: Autosomal Dominant
Acromegaly
Common Conditions: Cushing's Disease (and Addisons, can't avoid it)
Mercury and Lead Toxicity
Calcium
Psych Drugs, Psych Conditions, and Bone Health
NMT/Ortho Synthesis IV (week 1): Extremities
Beer Prevents Osteoporosis
Expect Bone Fractures if you take Fosamax Too Long
Treatments that Increase Serotonin Also Lower Bone Density
Collagen: On Wound Healing and some Pathologies
Vitamin D, Parathyroid, and BONES

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Entries tagged with bones

another member in the Pre-Human Family?

Environmental Medicine (week 6 & 7): Heavy Metals

Herbs: Menopause, Hormone Replacemnet

Mineral Nutrition: Copper, Iodine, Zinc, Manganese

Conditions: Osteoporosis

New Data on Calcium and Vitamin D Supplementation

Renal Tubular Acidosis

Vitamin D deficiency in pts with Hyperparathyroid

Genetics (week 5): Inheritance: Autosomal Dominant

Acromegaly

Common Conditions: Cushing's Disease (and Addisons, can't avoid it)

Mercury and Lead Toxicity

Calcium

Psych Drugs, Psych Conditions, and Bone Health

NMT/Ortho Synthesis IV (week 1): Extremities

Beer Prevents Osteoporosis

Expect Bone Fractures if you take Fosamax Too Long

Treatments that Increase Serotonin Also Lower Bone Density

Collagen: On Wound Healing and some Pathologies

Vitamin D, Parathyroid, and BONES