liveonearth: (sexy tits)
Modulation of autoimmune rheumatic diseases by oestrogen and progesterone
• Grant C. Hughes & Divaker Choubey
Nature Reviews Rheumatology 10, 740–751 (2014) doi:10.1038/nrrheum.2014.144
Published online 26 August 2014
http://www.nature.com/nrrheum/journal/v10/n12/full/nrrheum.2014.144.html
Abstract
Sexual dimorphism is evident in the risk and expression of several human autoimmune diseases. Differences in disease manifestations observed between sexes are likely to involve immunomodulation by sex steroids, nonhormonal factors encoded by genes on the X and Y chromosomes, and immunological phenomena unique to pregnancy. In systemic lupus erythematosus (SLE), and perhaps other autoantibody-mediated diseases, oestrogen seems to increase the risk of disease in genetically predisposed women by targeting key immune pathways, including the type 1 interferon (IFN) response, differentiation of CD4+ T helper cells and survival of autoreactive B cells. By contrast, progesterone seems to reduce the risk of SLE by counteracting the effects of oestrogen on some of these same pathways, which suggests that the balance between oestrogen and progesterone can determine disease expression. In this Review we focus on the roles of the sex steroid hormones oestrogen and progesterone in modulating the risk and expression of SLE and rheumatoid arthritis. Intensive research in this area promises to identify novel therapeutic strategies and improve understanding of the immunological requirements and complications of pregnancy, and is expected to define the mechanisms behind sexual dimorphism in autoimmunity, immunity and other aspects of human health—a newly announced directive of the NIH.
liveonearth: (Default)
The gist of the new finding by Dr Schor is that many hypothyroid patients may be missed because up to now nobody has realized that TSH levels fluctate on a pattern not much different from cortisol. This is no surprise to me since I have already learned that when we awaken naturally in the morning, it coincides with an increase on our body temperature, whereas when we fall to sleep, our bodies cool down. Thyroid hormone is a heater upper; without it you are cold. Based on what I know of the release patterns of TSH (thyroid stimulating hormone), CRH (cortisol releasing hormone), and GH (growth hormone), I am going to assume that all hypothalamic hormones follow a diurnal rhythm, and that it is possible that they might all pulse in the pre-dawn hours and decrease in the afternoon.
notes from email newletter )
liveonearth: (Default)
Market traders make more money on days when their morning testosterone is higher. A great article entitled "What Traders’ Testosterone Tells Us About Markets" explains the details, or you can scan my notes behind the cut.

Market participants aren’t the rational automatons of most financial theory. They are biological organisms responding with a neural and physiological apparatus designed millions of years ago. If what happens in markets affects hormones, these in turn alter behavior and feed back into the markets.

notes on the article )
liveonearth: (Default)
Sleep increases growth hormone and decreases IL-6. (Jones)
liveonearth: (Default)
Why? It is the #1 diet fad in the world right now. And it was WORKING for lots of people, and did not require a prescription. Or was it really because it was dangerous? We shall see.
http://www.medpagetoday.com/ProductAlert/OTC/30042?utm_source=breaking-news&utm_medium=email&utm_campaign=breaking-news#.Tt5Y7Lifxrw.facebook

Here's a decent orientation about the HCG diet if you haven't heard:
liveonearth: (endless_knot)
and including Persistent Organic Pollutants and Plastics
Kids with exposure to nature have less ADHD
notes )
liveonearth: (Default)
Metformin treatment has a TSH-lowering effect in hypothyroid patients with PCOS, both treated with l-thyroxine and untreated

http://www.medscape.com/viewarticle/748073?src=mp&spon=22



Insulin plus elevated LH causes increased Testosterone production in ovary
(Windstar)
liveonearth: (Default)
http://www.medscape.com/viewarticle/745359?src=mp&spon=34
is a review on this study:

Wilson KM, Kasperzyk JL, Rider JR, et al. Coffee consumption and prostate cancer risk and progression in the health professionals follow-up study. J Natl Cancer Inst. 2011;103:876-884. Epub 2011 May 17.

but this study
http://cancerres.aacrjournals.org/content/50/21/6836.short
found no correlation at least for survival of fatal prostate cancer, between coffee drinkers or not.

...and... coffee drinkers have higher testosterone! text here. video at link above. )
liveonearth: (Donkey)
They don't mention the fact that adipose tissue actually MAKES estrogen. Grow a gut and the moobs are soon to come.
article )
liveonearth: (Default)
http://www.zacks.com/stock/news/52768/FDA+Approves+Abbott's+AndroGel
It's supposedly for hypogonadal adult males but we shall see who gets scripts.
liveonearth: (Default)
From: denvernaturopathic
Date: Tue, Jan 11, 2011 at 11:40 AM
Subject: Thyroid works better taken at bedtime
contrary to what we've been told )

Acromegaly

Dec. 16th, 2010 10:36 pm
liveonearth: (Default)
What are the face, skull and foot changes seen with acromegaly?
more )

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