WHITE CELL NEOPLASMS
--malignant proliferation dz is the most imp disorder of WBC
--two main types: lymphoid and myeloid
--lymphoid neoplasms incl: Hodgkin's lymphoma and non-Hodgkin's lymphoma
--myeloid neoplasms incl: proliferation of abn hematopoietic cells (AML, ALL, CML, CLL), myelodysplastic syndromes (MDS), histiocytoses, plasma cell dz (multiple myeloma)
--histological exam (biopsy) of lymph nodes or other involved tissue required for Dx
--in most lymphoid neoplasms, antigen receptor gene rearrangement precedes transformation, can be used to distinguish reactive and malignant lymphoid proliferations
--majority of lymphoid neoplasms are of B-cell origin (80-85%)**
--cause immune abnormalities
( from pathology notes )