liveonearth: (dont_be_heavy)

  • This epidemiologic analysis revealed that mortality rates are increasing in the middle-aged white male population, largely due to preventable conditions like poisonings and overdoses.

  • Reductions in mortality were seen in other racial groups.

ARTICLE from Medpage, primary care )


SOURCE

http://www.medpagetoday.com/PrimaryCare/GeneralPrimaryCare/54456
liveonearth: (part of the solution)
absorption iz stomach (25%)
metabolized to acetaldehyde by stomach and LI
rate limiting enzyme: gastric alcohol dehydrogenase
men have more of it than women, per pound body wt
metabolism of ethanol-->acetaldehyde-->acetate
one NAD+-->NADH with each of above oxidation rxns
drinking binge w/o food intake-->high NADH relative to NAD
and of course you remember that NADH is made from niacin, vitamin B3
alcohol abuse is the most common cause of thiamine deficiency, B1

biochemistry, nutrition and pathology notes, merged with black book feb 2013 )
liveonearth: (skull candle book)
"The search for unpolluted drinking water is as old as civilization itself. As soon as there were mass human settlements, waterborne diseases like dysentery became a crucial population bottleneck. For much of human history, the solution to this chronic public-health issue was not purifying the water supply. The solution was to drink alcohol. In a community lacking pure-water supplies, the closest thing to "pure" fluid was alcohol. Whatever health risks were posed by beer (and later wine) in the early days of agrarian settlements were more than offset by alcohol's antibacterial properties. Dying of cirrhosis of the liver in your forties was better than dying of dysentery in your twenties. Many genetically minded historians believe that the confluence of urban living and the discovery of alcohol created a massive selection pressure on the genes of all humans who abandoned the hunter-gatherer lifestyle. Alcohol, after all, is a deadly poison and notoriously addictive. To digest large quantities of it, you need to be able to boost production of enzymes called alcohol dehydrogenases, a trait regulated by a set of genes on chromosome four in human DNA. Many early agrarians lacked that trait, and thus were genetically incapable of "holding their liquor." Consequently, many of them died childless at an early age, either from alcohol abuse or from waterborne diseases. Over generations, the gene pool of the first farmers became increasingly dominated by individuals who could drink beer on a regular basis. Most of the world population today is made up of descendants of those early beer drinkers, and we have largely inherited their genetic tolerance for alcohol. (The same is true of lactose tolerance, which went from a rare genetic trait to the mainstream among descendants of the herders, thanks to domestication of livestock.) The descendants of hunter gatherers--like many Native Americans or Australian Aborigines--were never forced through this genetic bottleneck, and so today they show disproportionate rates of alcoholism. The chronic drinking problem in Native American populations has been blamed on everything from the weak "Indian constitution" to the humiliating abuses of the U.S. reservation system. But their alcohol intolerance most likely has another explanation: their ancestors didn't live in towns."
--Steven Johnson, in The Ghost Map, pages 103-4.
liveonearth: (Default)
Supplements 101:
the Who What and Why of Dietary Supplement Manufacturing and Use in Clinical Practice

IATROGENIC AND OTC HYPOCHLORHYDRIA
tabs also not good for pts who are taking acid blocking meds (tagamet, etc)
without acid: don't digest proteins, don't absorb minerals
shakes bottle of tabs: as good as a maraca if you don't have acid
blocked acids in rats: made them more allergic to foods
http://www.ncbi.nlm.nih.gov/pubmed/17227952?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3
he asked the researcher, they're doing it in humans, same results
guest lecturer week 7, this post has been moved forward in time: what forms of vitamins to take? good info here, esp on folate as relates to neurotransmitter manufacture )
liveonearth: (Default)
http://www.medscape.com/viewarticle/745359?src=mp&spon=34
is a review on this study:

Wilson KM, Kasperzyk JL, Rider JR, et al. Coffee consumption and prostate cancer risk and progression in the health professionals follow-up study. J Natl Cancer Inst. 2011;103:876-884. Epub 2011 May 17.

but this study
http://cancerres.aacrjournals.org/content/50/21/6836.short
found no correlation at least for survival of fatal prostate cancer, between coffee drinkers or not.

...and... coffee drinkers have higher testosterone! text here. video at link above. )
liveonearth: (Default)
http://www.jarrow.com/product/188/Neuro_Optimizer consider this product via Vitacost



MY QUESTIONS
what are food sources of citicholine? can we get it from eating brains?
there is choline in eggs and liver. is there citicholine?? how much??
how easily does choline convert to citicholine?
can we support the conversion?
can we by pass this supp using diet???

CHOLINE DEFICIENCY is common (not citicholine, mind you!)
suspect if: fatty liver, hemorrhagic kidney necrosis, infertility, growth impairment, bone abnormalities, hypertension, cancer, atherosclerosis, glaucoma, neuro dz: Alzheimer's,. bipolar. LABS: incr ALT, incr HCYS

notes, some background, links )
liveonearth: (Default)
Francis Brinker ND
1981 NCNM grad, prof at SCNM and U of Az College of Med
Botanical Pharmacokinetic Interactions with Drugs and Botanical Adjuncts
with NSAIDS & Analgesics for Arthritis
Useful Website: http://medicine.iupui.edu/clinpharm/DDIs/table.aspx
**print interaction summary page from moodle
consumer info: http://WWW.DRUGDIGEST.ORG/WPS/PORTAL/DDIGEST
arthritis part of talk at the very end, first part of talk all about drug interactions
interactions with St John's Wort, Ginkgo, Ginseng, Garlic, Peppermint, and as usual Grapefruit
notes )
liveonearth: (Default)
Because mercury bio-accumulates, and otters are SO carnivorous, they are like the canary in a coalmine for the detection of mercury. The Wisconsin Dept of Natural Resources asked all the otter trappers for the carcasses and tested various tissues for mercury levels. The levels were highest in fur, with descending concentrations in these tissues: liver, kidney, muscle, and brain. Methyl-mercury made up a greater percentage of total Hg in brain and muscle compared to liver and kidney tissue. So far none of the otters appears to be sickened by their mercury load. The levels in the fur are directly related to the levels in internal tracking, so I suspect future research may follow living otters to see what they're taking in. "A gradient" in tissue concentrations was noted from north to south, but they don't say which way the gradient goes. Perhaps more to the south, like in fish? We shall see.

SOURCES
http://dnr.wi.gov/environmentprotect/pbt/research/OtterSummaryAbstract.pdf
http://www.springerlink.com/content/m4pg0184615kr4hk/
http://www.ncbi.nlm.nih.gov/pubmed/17926081

Also, at http://www.glc.org/glad/projects/basu09/ they are monitoring eagles and otters for biomarkers. The specific aims of this proposal are: 1) Exposure Assessment : to determine tissue mercury and PBDE levels in river otters and bald eagles from several Great Lakes states, with a focus on animals collected from existing statewide monitoring programs in Michigan and Wisconsin; 2) Health Assessment : to determine river otter and bald eagle health status by means of neurochemical biomarker studies on key receptors (muscarinic, glutamate) and enzymes (monoamine oxidase, cholinesterase) in physiologically important brain regions; 3) Risk Characterization : to determine if there is a statistical association between mercury and PBDE exposure (Aim #1) and alterations in neurochemical biomarkers (Aim #2); and 4) Education and Capacity Building : to build capacity among academic researchers and government/state managers and to disseminate results to scientific and regulatory communities.
liveonearth: (Default)
Funny how exciting a revelation like this can be to me. I finally understand why in alcoholic liver disease the AST is often elevated more than the ALT. Also the GGT may be normal. Why? Because both AST and GGT are dependent on vitamin B6 for their manufacture, and that particular nutrient is depleted by heavy drinking. Ha. Why didn't somebody tell me that years ago?
liveonearth: (Default)


Hep A virus, or "HAV", causes a relatively benign, self-limiting disease.
more )

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