INTERESTING TIMES

If you live and Portland and haven't picked up a copy of this month's Willamette Week (free news weekly, online here: http://www.wweek.com/portland/index.php), this issue is likely to get snapped up. They've named it the 420 Issue and it is all about the businesses and culture incurred by the recent legalization of cannabis in Washington and soon Oregon. What struck me initially is the amount of wordplay around the subject, and the generation of witty new phrases, words and hashtags that accompanies the surge in businesses and products containing cannabinoids. There is great excitement about the new availability and openness that comes with legalization.

I for one am OK with recreational and medical use. I think that the risks to society of adults using cannabinoids are fairly minimal. It certainly doesn't make people drive dangerously the way alcohol does. It does have a whole set of risks that aren't covered in this issue, and that really need to be kept high in our awareness as this drug becomes widely acceptable.

One risk that is coming into focus these days is of extreme overdoses. Back when folks just inhaled smoke, coughing stopped them from partaking too much. Vaporizers now make inhalation gentler and it is easy to overdose when consuming edibles. With either method you can't tell how much intoxicant is in there. With humans ingeniously extracting and concentrating the active principles, it could be very strong, or contaminated with solvents. With edibles the effect takes time to kick in. It is terribly easy to overdose for folks who are experimenting for the first time, and who have no tolerance at all.

The conventional media take on overdose--blaming it for many deaths and claiming that it is deadly--is probably overblown. It takes a massive amount of pot to kill, perhaps more than anybody is likely to actually reach because unlike opioids it is so unpleasant getting there. It is however a relative unknown: having been illegal for so long, we don't have scientific studies about overdose. We hardly have science to justify all the medical uses that have already been approved. We are going to find out now.

Another risk is incurred by the fact that edibles make the drug palatable to people who would never smoke it. It is tempting to children as candy. There is the danger that children, teens and early 20-somethings will enjoy sugary yummies containing cannabinoids and permanently alter their brain development. Later on in life there is still a brain changing effect, but in early life when the brain is still forming, the effect can be severe.

On top of these new risks due to the availability of edibles, there is the old risk of respiratory injuries resulting in sinusitis and bronchitis, and risk of more dangerous conditions like pneumonia and COPD. There is also the fact that marijuana increases heart rate significantly in most individuals. Folks who already have hypertension or heart palpitations might give themselves a heart attack.

I suppose my main message in the light of all this 420 excitement is BE CAUTIOUS and PROTECT YOUR CHILDREN because there is a lot we don't know. I believe in freedom and individual discretion as most Americans do, and I also know that people can be terribly foolish and injure themselves and others, especially when intoxicants are involved. I cannot protect the whole world from poor choices, but I do hope that this warning is heard widely. Please take care of each other and if you are going to play with the newly legalized products, start very small.

I'm not big on woo woo. When practitioners choose modalities simply because they "resonate" with them, I am skeptical. But when science backs up the use of something that has long been thought of as energy medicine, I am happy to recommend it. Of course people will tell you something is backed by science when it isn't, so you have to go look at the science for yourself, or find sources like me that you know are science-minded and skeptical to help filter the claims for you.

Here's a case of energy medicine turning out to be something real. Scientists have found that acupuncture points are detectable by CT (computed tomography, fancy medical imaging). All those points have a certain size of larger blood vessels, and also thick mats of fine blood vessels that have lots of forks (birfucations) in them. Piercing the tissues at these points is probably affecting the nervous system associated with those blood vessels. This supports my belief that energy medicine (that actually works) has a anatomical and physiological basis. Acupuncture is well proven to be effective for pain, short term at least. To treat pain longterm one must take the naturopathic approach and find the reason for the pain, and change that.

The study in question (Women's Health Study) reaffirmed this association, in this case specifically for postmenopausal females. Certainly other populations are likely to be affected as well.

Nice article here: http://naturalmedicinejournal.com/article_content.asp?edition=1§ion=3&article=330

Physicians are faced with a basic question when making a prescription of any drug to a patient: “What are the risks and benefits of this recommendation?” When it comes to statin drugs, the benefits have been grossly overstated, while the risks have continually been swept under the rug. That discussion is much longer than the space available in this commentary. Suffice it to say that it is important to point out that while statins reduce the heart attack risk in women, they do not appear to affect overall risk of death, possibly because an increased risk for diabetes cancels out the reduced heart attack risk. So, let me focus on the study at hand and try to make sense of such a high risk for diabetes in postmenopausal women using statins.

http://articles.mercola.com/sites/articles/archive/2099/12/31/dangers-of-salt-restriction.aspx?e_cid=20120213_DNL_artTest_C3

Bottom line: "real" salt (ie from the earth or sea) contains oodles of minerals that support heatlh. Eating this salt is beneficial to health. Eating processed NaCl with added iodine is not as beneficial, but it still supports adrenal function and fluid balance. Ceasing sodium consumption can be destructive to your health. Don't listen too carefully to the FDA, whatever you do.

Cardiac devices. Yep. Most of them are covered by insurance. All those fancy gizmos that they are so eager to install in us, whenever we have a little heart trouble, those gizmos are increasingly suspect. The situation has gotten so bad that the GAO is pushing the FDA to take a more active role in overseeing devices used by the cardiac care medical industry.

During the period covered by the report ('05-'09), medical-device makers initiated 3510 device recalls, which cover everything from "field corrections" to revised labeling to retrieving a device from customers. The agency categorized about 83% of these recalls as class II, indicating the devices may cause temporary adverse health consequences, and 14% as class III, indicating the device is not likely to cause any adverse consequences. Only 4% were class I recalls, deemed by the FDA to have a reasonable risk of causing serious adverse health consequences or death.

During this time, cardiovascular devices were the most commonly recalled products: 532 recalls, making up 15% of all recalls during this period, while the 40 class-I recalls of cardiovascular devices represented 31% of all class-I recalls in the period. The largest number for cardiovascular devices involved automatic external defibrillators.

The next most common category is radiological devices, which accounted for 484 total recalls but only two class I recalls, followed by general hospital and personal-use devices, which accounted for 388 recalls overall, including 31 class I recalls.

SOURCE
http://www.theheart.org/article/1244193.do?utm_campaign=newsletter&utm_medium=email&utm_source=20110627_EN_Heartwire

Cardio and Resp
( notes )

opioid analgesic use and abuse on the rise
types: codeine, hydrocodone, meperidine, oxycodone, propoxyphene, morphine, tramadol, methadone, hydromorphone, fentanyl, pentazocine

therapeutic opioid use reported by 2.6% of 17,449 case mothers
2.0% of 6701 control mothers
mc: codeine (34.5%), hydrocodone (34.5%), oxycodone (14.4%), meperidine (12.9%)

time window studied: 1 mo before conception to 3 mo after

2-3x risk of infant defects:
conoventricular septal defects = opening btw ventricles not assoc w/ other congenital CV defect
atrioventricular septal defects = hole in upper vent septum assoc w/ atrial septal defect, incr lung circ
hypoplastic left heart syndrome = bad prognosis, rare, incomplete development of mitral valve, left ventricle, aortic valve, and/or aorta
spina bifida = embryonic neural tube not closed
gastroschisis = abd wall defect, hole near umbilicus thru which intestines and mb other organs develop outside, aka paraomphalocele, laparoschisis, abdominoschisis, abdominal hernia

SOURCE
medscape: http://www.medscape.com/viewarticle/738236?src=mpnews&spon=12