liveonearth: (part of the solution)
absorption iz stomach (25%)
metabolized to acetaldehyde by stomach and LI
rate limiting enzyme: gastric alcohol dehydrogenase
men have more of it than women, per pound body wt
metabolism of ethanol-->acetaldehyde-->acetate
one NAD+-->NADH with each of above oxidation rxns
drinking binge w/o food intake-->high NADH relative to NAD
and of course you remember that NADH is made from niacin, vitamin B3
alcohol abuse is the most common cause of thiamine deficiency, B1

biochemistry, nutrition and pathology notes, merged with black book feb 2013 )
liveonearth: (Default)
Supplements 101:
the Who What and Why of Dietary Supplement Manufacturing and Use in Clinical Practice

IATROGENIC AND OTC HYPOCHLORHYDRIA
tabs also not good for pts who are taking acid blocking meds (tagamet, etc)
without acid: don't digest proteins, don't absorb minerals
shakes bottle of tabs: as good as a maraca if you don't have acid
blocked acids in rats: made them more allergic to foods
http://www.ncbi.nlm.nih.gov/pubmed/17227952?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3
he asked the researcher, they're doing it in humans, same results
guest lecturer week 7, this post has been moved forward in time: what forms of vitamins to take? good info here, esp on folate as relates to neurotransmitter manufacture )
liveonearth: (Default)
Not just for the Chinese medicine practitioners... I've been taking note of tongues for a couple years now and they do tell quite a tale of a person's insides.

Nice article here from someone at Stanford U:
http://stanford25.wordpress.com/the-tongue-in-diagnosis/
liveonearth: (Default)
I'm not taking notes on the cases themselves, just on factoids.
notes )
liveonearth: (pharm: handful a day keep docs at bay)
The potentially dangerous ones are iron if you're middle aged and female are: multivitamins, vitamin B6, folic acid, beta carotene, magnesium, zinc, and copper. They used data from the Iowa Women's Health Study, which collected data on 38,772 women aged 55 to 69. From that sample, 15,594 died during the study period, which was about 40% of the initial group! Geeze. The people who took supplements were more educated, more physically active and more likely to get supplemental estrogen. Vitamin B6, folic acid, iron, magnesium, and zinc were associated with about a 3% to 6% increased risk for death, whereas copper was associated with an 18.0% increased risk for total mortality when compared with corresponding nonuse. On the other hand, women who took calcium were more likely to live longer (3.8% risk reduction).

My theory: people take more vitamins when their diet is crap. I know I do this. I'll eat a dinner of popcorn and ice cream and supplements sometimes. But when I eat fresh organic veggies and meat, I skip the supps and don't worry about it. Perhaps we "older" women are using our pills to justify a terrible diet. Maybe? Guess I better start taking my calcium, though.

Absolute risk increase (total mortality)
multis 2.4%
B6 4.1%
folic 5.9%
iron 3.9%
magnesium 3.5%
zinc 3.0%
copper 18.0%

SOURCES
http://www.medscape.com/viewarticle/751263?src=mpnews&spon=34
Arch Intern Med. 2011;171:1625-1633,1633-1634
http://archinte.ama-assn.org/cgi/content/short/171/18/1625
http://archinte.ama-assn.org/cgi/content/extract/171/18/1633
liveonearth: (Default)
Pretty interesting overview of the newest attack here on Natural News: FDA's scheme to outlaw nearly all nutritional supplements created after 1994 would destroy millions of jobs and devastate economy. In the new proposed rules synthetic nutrients are exempted. The target of administrative control appears to be animal and plant-derived supplements. Botanicals. There are many health practitioners who prefer to use natural products as opposed to chemically synthesized ones. But the FDA wants to put us under. It's too dangerous to eat plants and animals; the content is not standardizable. We don't really know what's in there.

More here. You can make noise there too by signing the petition if you care.

And I did not know this, but the FDA has already banned the P5P form of vitamin B6---which some people cannot manufacture on their own and must get from their diet. They're basically trying to trap us into purchasing pharmaceuticals when relatively inexpensive natural alternatives exist. Because some people need to take top quality B6 for life (because of inherited metabolic handicaps), they see a market, just like any drug they can get you to buy for life. It's much more profitable for pharmaceutical corporations to make drugs that you need forever more.

It's time to start gardening, folks. They can't keep us from eating the weeds that grow by our house.
liveonearth: (part of the solution)
Denise Burnham of Creative Compounding speaking
notes )
liveonearth: (Default)
Funny how exciting a revelation like this can be to me. I finally understand why in alcoholic liver disease the AST is often elevated more than the ALT. Also the GGT may be normal. Why? Because both AST and GGT are dependent on vitamin B6 for their manufacture, and that particular nutrient is depleted by heavy drinking. Ha. Why didn't somebody tell me that years ago?
liveonearth: (Default)
http://news.bbc.co.uk/2/hi/health/10318410.stm

Add to this info that not everybody can use the form of B6 that is in cheap vitamins. About 1/4 of us have to buy the fancy B6 that is activated by methylation, because for genetic reasons we aren't good at methylating our own. Methylation is one of the main pathways by which your liver makes toxic lipophilic compounds water soluble so they can be excreted. B6 is key for supporting methylation, but if you can't methylate, you can't activate the B6 you get, so you MUST buy the supplement! For example, B6 is depleted in women who take birth control pills, and remains depleted for years after they stop. Just a FYI! I always have wanted to believe that I could get all the nutrition I needed from food, but I'm not so sure anymore. Considering the increasing insults of toxins and hormonally active substances in our environments, we can use all the help we can get. Provided we can figure out what is helpful and what is not. It is not so obvious....
liveonearth: (Default)
What do you suspect if your patient chronically has canker sores in her mouth?
gluten enteropathy

What is the biggest difference between modern human diets and that of paleolithic humans?
we eat more grass family foods now
(wheat, corn, barley, oats, rice, ie: grains, agriculture)

What is the natural expiration age for humans?
somewhere between 110 and 120 years of age

What are the top five causes of death in the US?
CV dz, CA, medical care, DM, stroke
scroll on down to see what you know )
liveonearth: (Default)
Methotraxate is one of the drugs often used in chemotherapy. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme dihydrofolate reductase. Without this enzyme, the cells are starved for tetrahydrofolate, and unable to make purines (adenine, guanine) and dTPM. This is especially toxic to fast-growing cells, like cancer cells.

How does a cancer become resistant to this drug?
answer )

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