INTERESTING TIMES

Valter Longo has proved this to be true for mice, and now has human trials ongoing to determine if it's true for us too. It worked for the first 10 people, they didn't eat for two days prior to the administration of chemotherapy and felt much better.
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Methotraxate is one of the drugs often used in chemotherapy. It interferes with folate metabolism by acting as a competitive inhibitor of the enzyme dihydrofolate reductase. Without this enzyme, the cells are starved for tetrahydrofolate, and unable to make purines (adenine, guanine) and dTPM. This is especially toxic to fast-growing cells, like cancer cells.

How does a cancer become resistant to this drug?
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