A group of clinically and biochemically diverse diseases characterized by proliferation of ONE clone of plasma cells normally engaged in immunoglobulin production. PCD's account for 15% of WBC neoplasms. Typified by the presence of a monoclonal Ig or polypeptide subunit (fragment) in serum or urine. Monoclonal immunoglobin in the blood is referred to as "M component".
All are composed of terminally differentiated B cells, arise in the bone marrow, secrete whole Ab's or immunoglobulin fragments, cause bony destruction. Patients present with pain dt pathologic fractures.
Five types including related disorders:
1) Multiple Myeloma
2) Waldenstrom's macroglobulinemia
3) Heavy Chain dz
4) Primary or immunocyte-associated amyloidosis
5) MGUS = Monoclonal gammopathy of undetermined significance. MGUS is common in elderly pts and has no signs or symptoms.
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All are composed of terminally differentiated B cells, arise in the bone marrow, secrete whole Ab's or immunoglobulin fragments, cause bony destruction. Patients present with pain dt pathologic fractures.
Five types including related disorders:
1) Multiple Myeloma
2) Waldenstrom's macroglobulinemia
3) Heavy Chain dz
4) Primary or immunocyte-associated amyloidosis
5) MGUS = Monoclonal gammopathy of undetermined significance. MGUS is common in elderly pts and has no signs or symptoms.