INTERESTING TIMES

final will be case based and we prob will see at least one of these cases: know leukemia
( notes )

GENERAL NOTES:
--myeloid neoplasms incl: leukemias, myelodysplastic syndromes, histiocytoses, plasma cell dz
--malignant neoplasm of blood-forming tissue-->marrow replacement
--decreased apoptosis of cells --> increase in #'s
--ETIO: HTLV-1, oncogenes (p53), envir: EMF, benzene, radiation, x-rays, chemo drugs
--malignancy is found in 50% of pts with unexpected increased platelet counts (esp CML)
--acutes have immatures in PB, esp blasts
--chronics have more mature cells
--over 30% blasts in marrow usu means leukemia
--best way to differentiate btw B-cell and T-cell types: immunophenotyping
( notes on four kinds of leukemia and myelodysplasia (pre-leukemia) )