liveonearth: (Default)
--the GI tract has 400 square meters of surface area and over 500 species of bacteria
--less TLR's on macrophages and DC's in gut
--some enteric microbes no longer bind TLR's (bifidus)
--food in lumen crosses mucosa to peyers patches, mesenteric lymph nodes
--peyers patches and mesenteric lymph nodes constitute 80% of a person's immune system
--always active
--eating oil with food causes it to be absorbed lower in the tract, increasing the odds of allergy because there are more allergens down there
--TGFbeta is the 2nd signal to shut down T cells ???
--M cells are between peyers patch and lumen
--M cells transport food via endosome to PP
--epithelial cells also take in food, have MHC-I
Expandnotes, not very clear yet )
liveonearth: (Default)
SPOROTRICHOSIS

These notes are with regard to a case I know of a woman who was bitten in her hands by a cat and 8 years later still has inflammation in the bitten knuckles. Most people acquire this infection via a small wound from a single thorn stick (rose gardeners), not direct innoculation into a joint. But this is what I think is going on, and why.
Expandmore )

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liveonearth

May 2025

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