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liveonearthIn a couple weeks I am to deliver a presentation, along with a classmate, on a 3-4 products that are available through the NCNM Medicinary. I am going to take notes on one of them here. In front of me I have a MUCAPLEX bottle, so I'm starting with what's on the label.
MUCAPLEX
(formerly Bronchoril) a guaifenesin expectorant
from: integrative THERAPEUTICS, INC.
Green Bay, WI 54311
www.integrativeinc.com
1-800-931-1709
LABEL CONTENTS
NCD #59800-7232-1
Helps thin and loosen mucus, making coughs more productive and clearing respiratory airways.
100 tablets
Warning: do not take for persistent or chronic cough ie: smoker, asthma, chornic bronchitis, emphysema, or where cough is accompanied by excessive mucus (unless directed by doc)
Stop if: cough lasts over one week, is recurring, or is accompanied by fever, rash, persistent headache
Ask if: preg or breast feeding
NOT sure what this number is, but it's printed at 90 degrees to the rest: l172321.E02
DOSAGES
adults and kids over 12: 1-2 tabs every 4 hours, not more than 12 tabs in 24 hours
age 6-12: 1/2-1 tabs same timeframe
under 6: consult doc
ACTIVE INGREDIENTS: GUAIFENESIN
guaifenesin = glycerol guaicacolate 200mg in each tablet (label)
Guaifenesin (INN) or guaiphenesin (former BAN) aka glyceryl guaiacolate (wiki)
??what's the difference between glyceryl and glycerol??
glycerol = a sweet syrupy trihydroxy alcohol
obtained by saponification of fats and oils
glyceryl = a trivalent radical derived from glycerol
by removing the three hydroxyl radicals
OTC PO expectorant, usually in pill or syrup form, many brands
from the guaiac tree aka gum tree
(not sure if these images are the right plant)
generic remedy of Native Americans in 1500's
FDA approved in 1952
mb combined with dextromethorphan (antitussive, most common combo, goal: fewer but more productive coughs), pseudoephedrine/phenylephrine, acetaminophen, poss codeine
a component of Robitussin DAC, Mucinex and Robitussin AC
single ingredient formulations also available
OTHER USES OF GUAIFENESIN
COUGH, ASTHMA
anecdotal support for these usages but Cochrane review finds the evidence for guaifenesin "ambiguous:
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001831/frame.html
http://www.cochrane.org/reviews/
GOUT (mild uricosuric, incr excretion of uric, discovered by chance)
fibromyalgia (some say it cures fibro by removing excess phosphate, Dr Paul St Amand, 1990's, "the guaifenesin protocol")
Fibromyalgia Network's website warns that claims re: fibro are groundless
http://www.fmnetnews.com/resources-alert-product6.php)
double blind research by Robert Bennett, M.D. found no sig diff btw guaifenesin and placebo for fibro or markers
FERTILITY
thin cervical mucus
only one very small study without controls
the rest anecdotal
SEs (none on label)
dry mouth
OVERDOSE SIDE EFFECTS
nausea, vomiting
rare: uric acid kidney stones
OTHER INSTRUCTIONS
maintain good hydration
take with meals (reduces N/V)
PRIMARY DYSMENORRHEA
small double-blind placebo-controlled found it reduced dysmenorrhea but not significantly
SINGERS
"wonder drug" promote secondary mucosal secretion in resp sys
secondary mucus = thinner, lubricating mucus on vocal folds when they are healthy
used in extremes of weather (very wet or very dry), after flying, during mild allergies
only source is pop article, no science
ANALGESIC EFFECT
neuro properties known in late 1940's
skeletal muscle relaxant
possible inhibition of platelet aggregation
used as anesthetic in horses and llamas, less hemolytic than propanediols, more water soluble
INACTIVE INGREDIENTS (PER LABEL)
sodium 10mg
carnauba wax
cellulose
fenugrek (Trigonella foenum-graecum) seed extract 4:1
magnesium stearate
marshmallow (Althea officinalis) root extract 3.5:1
modified cellulose
modified cellulos gum
mullein (Verbascum thapsus) leaf
PABA (para-aminobenzoic acid)
soy lecithin
stearic acid
"This label conforms to FDA labeling regs for OTC products.
Claims on label:
"fast acting"
"non-drowsy"
"safe for adults and children"
"evidence based natural medicines are the only choice of doctrs who rely on the fact base of premier scient to deliver patient results"
CONTAINS NO
sugar
yeast
wheat
gluetn
corn
dairy
artificial coloring or flavoring
preservatives
animal origin ingredients
ON BOTTOM OF BOTTLE:
LOT A1 92946 EXP 02/20/11
packaged in HDPE plastic #2 white in color
SOURCES:
product label
wikipedia
http://en.wikipedia.org/wiki/Guaifenesin
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001831/frame.html
MUCAPLEX
(formerly Bronchoril) a guaifenesin expectorant
from: integrative THERAPEUTICS, INC.
Green Bay, WI 54311
www.integrativeinc.com
1-800-931-1709
LABEL CONTENTS
NCD #59800-7232-1
Helps thin and loosen mucus, making coughs more productive and clearing respiratory airways.
100 tablets
Warning: do not take for persistent or chronic cough ie: smoker, asthma, chornic bronchitis, emphysema, or where cough is accompanied by excessive mucus (unless directed by doc)
Stop if: cough lasts over one week, is recurring, or is accompanied by fever, rash, persistent headache
Ask if: preg or breast feeding
NOT sure what this number is, but it's printed at 90 degrees to the rest: l172321.E02
DOSAGES
adults and kids over 12: 1-2 tabs every 4 hours, not more than 12 tabs in 24 hours
age 6-12: 1/2-1 tabs same timeframe
under 6: consult doc
ACTIVE INGREDIENTS: GUAIFENESIN
guaifenesin = glycerol guaicacolate 200mg in each tablet (label)
Guaifenesin (INN) or guaiphenesin (former BAN) aka glyceryl guaiacolate (wiki)
??what's the difference between glyceryl and glycerol??
glycerol = a sweet syrupy trihydroxy alcohol
obtained by saponification of fats and oils
glyceryl = a trivalent radical derived from glycerol
by removing the three hydroxyl radicals
OTC PO expectorant, usually in pill or syrup form, many brands
from the guaiac tree aka gum tree
(not sure if these images are the right plant)
generic remedy of Native Americans in 1500's
FDA approved in 1952
mb combined with dextromethorphan (antitussive, most common combo, goal: fewer but more productive coughs), pseudoephedrine/phenylephrine, acetaminophen, poss codeine
a component of Robitussin DAC, Mucinex and Robitussin AC
single ingredient formulations also available
OTHER USES OF GUAIFENESIN
COUGH, ASTHMA
anecdotal support for these usages but Cochrane review finds the evidence for guaifenesin "ambiguous:
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001831/frame.html
http://www.cochrane.org/reviews/
GOUT (mild uricosuric, incr excretion of uric, discovered by chance)
fibromyalgia (some say it cures fibro by removing excess phosphate, Dr Paul St Amand, 1990's, "the guaifenesin protocol")
Fibromyalgia Network's website warns that claims re: fibro are groundless
http://www.fmnetnews.com/resources-alert-product6.php)
double blind research by Robert Bennett, M.D. found no sig diff btw guaifenesin and placebo for fibro or markers
FERTILITY
thin cervical mucus
only one very small study without controls
the rest anecdotal
SEs (none on label)
dry mouth
OVERDOSE SIDE EFFECTS
nausea, vomiting
rare: uric acid kidney stones
OTHER INSTRUCTIONS
maintain good hydration
take with meals (reduces N/V)
PRIMARY DYSMENORRHEA
small double-blind placebo-controlled found it reduced dysmenorrhea but not significantly
SINGERS
"wonder drug" promote secondary mucosal secretion in resp sys
secondary mucus = thinner, lubricating mucus on vocal folds when they are healthy
used in extremes of weather (very wet or very dry), after flying, during mild allergies
only source is pop article, no science
ANALGESIC EFFECT
neuro properties known in late 1940's
skeletal muscle relaxant
possible inhibition of platelet aggregation
used as anesthetic in horses and llamas, less hemolytic than propanediols, more water soluble
INACTIVE INGREDIENTS (PER LABEL)
sodium 10mg
carnauba wax
cellulose
fenugrek (Trigonella foenum-graecum) seed extract 4:1
magnesium stearate
marshmallow (Althea officinalis) root extract 3.5:1
modified cellulose
modified cellulos gum
mullein (Verbascum thapsus) leaf
PABA (para-aminobenzoic acid)
soy lecithin
stearic acid
"This label conforms to FDA labeling regs for OTC products.
Claims on label:
"fast acting"
"non-drowsy"
"safe for adults and children"
"evidence based natural medicines are the only choice of doctrs who rely on the fact base of premier scient to deliver patient results"
CONTAINS NO
sugar
yeast
wheat
gluetn
corn
dairy
artificial coloring or flavoring
preservatives
animal origin ingredients
ON BOTTOM OF BOTTLE:
LOT A1 92946 EXP 02/20/11
packaged in HDPE plastic #2 white in color
SOURCES:
product label
wikipedia
http://en.wikipedia.org/wiki/Guaifenesin
http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001831/frame.html
