White Cell Dyscrasias: MM, ALL, AML, CML, CLL, Hairy Cell

[liveonearth]

MULTIPLE MYELOMA
lytic lesions
plasma cells
hypercalcemia
Bence-Jones proteins in urine

ACUTE LYMPHOBLASTIC LEUKEMIA
most common leuk and CA in kids
incidence peak age 4
assoc w/ virus, Down's, radiation exposure
prog: good: remission or cure with tx
Sx: fever, bone pain, hepatosplenomegaly

ACUTE MYELOBLASTIC LEUKEMIA
aka acute nonlymphocytic leukemia
8 types
most common leuk in adults 15-39
poorly differentiated
prog: poor, live 1 year with chemo, cure 10-15%
auer rods

CHRONIC MYELOGENOUS LEUKEMIA
well-differentiated granulocytic
Philadelphia chromosome
age 25-60, slow for 3 yrs then blast crisis (85% die)
may include any cell line
hepatosplenomegaly, generalized LAD

CHRONIC LYMPHOCYTIC LEUKEMIA
most common leuk overall
most common after 60
well differentiated B-cell lymphocytic
more males, never Asian
few sx
prog: survive 4-6 yrs
acute state rare, unlike CML

HAIRY CELL LEUKEMIA
B cells w/ hairlike projections
virus related
pancytopenia
middle aged men
most survive over 10 yrs