Naturopathic Treatments, Zwickey Roundup and Case Studies

[liveonearth]

HYDROTHERAPY
--Hydrotherapy → Increase circulation of monocytes, Increase IL-1 → Fever → Increases innate immunity (IL-1, monocytes/macrophages), May increase antigen presentation for T cell response, Increases circulation—increase chances for T-APC interaction
--Use early and late in infection
--DO NOT use for autoimmune

STEROIDS INCL CORTISOL
--Glucocorticoids → decreases IL-12, Increases IL-6 → decrease Ag presentation, decrease lymphocyte proliferation, decrease NK activity, decrease chemokines
--TNFa sometimes up, sometimes down

STRESS MANAGEMENT
--Relaxation → Increase CD8 T cells, NK cells → Increase NK activity
--Macrophages express concentration dependent alpha and beta adrenergic receptors
--relaxation increases alpha, decreases beta
--low concentration of Epi/NE, alpha adrenergic (high affinity) → increase phagocytosis, TNFa, IL-6
--high concentration of Epi/NE, beta adrenergic (low affinity) → decreases phagocytoisis, decreases antigen processing and presentation, decreases production of IL-12
--Relaxation → Increase salivary IgA,Increases IFNg
--Relaxation increases Th1
--Use for allergies, pain and inflammation

PROBIOTICS
--In vitro evidence very different than in vivo evidence
--probiotics → Increases CD25+ T regulatory cells, TGFb, IL-10, IFNg in vitro
--When lactating mother take L. caseii, decreases TNFa in breast milk; less GI upset in infants.
--Reduces the number of carcinogens in the intestine (seems to drive a Th3 / Treg response)
--use for IBS, autoimmune, allergies, pregnant/breastfeeding

FISH OIL (high dose, ~14g/day, unless noted low dose)
--Enhance antioxidant enzymes
--Lower Th-1/Th-2 cytokines (Low doses lower Th2 only)
--Lower adhesion molecules
--Lower COX-2/PGE(2) levels
--Lower pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha)
--Immunosuppressive—or may drive T reg/Th3
--Use in cases of too much immune response – inflammation, autoimmunity

MONOUNSATURATED FATTY ACIDS (MUFA, ie olive oil)
--Suppression of lymphocyte proliferation
--Inhibition of cytokine production
--Reduction in natural killer (NK) cell activity.
--some studies that MUFA is more immunosuppressive than n-3 oils
--Use in cases of too much immune response – inflammation, autoimmunity

Case Study 1
A 36 year old male presents with head congestion, persistent cough, nausea (low-grade nausea). He doesn’t feel well. He is tired and fatigued, but is sleeping well. His symptoms have persisted for 5 days.

What’s going on with his immune system?

What do you want to do to the immune system?

What strategies could you employ?

How would you know if what you tried was working?


Case Study 2
A 48 year old female presents with type II diabetes. Her BMI is 42. She notices that she’s had increased pain, and she’s worried about cardiovascular disease. She has trouble losing weight.

What’s going on with her immune system?

What do you want to do to the immune system?

What strategies could you employ?

How would you know if what you tried was working?


Case Study 3
A 22 year old male presents with severe allergies. He’s allergic to cats, grass, ragweed, mold, and bunnies. He wonders if he has food allergies too since he gets diarrhea when he eats pizza, as some other foods.

What’s going on with his immune system?

What do you want to do to the immune system?

What strategies could you employ?

How would you know if what you tried was working?


Brainstorm
What would be some culturally defined characteristics that might affect an immune reponse?
diet, stress, sleep habits, drinking