Second Messengers: cAMP intracellular signalling and more

--second messenger = diffusable signaling molecule produced or secreted after signal is received
--molecule activates effector proteins inside cell-->cell response to signal
--can be synthesized/released and broken down again in specific rxns
--production, storage, and destruction can be localized
( this stuff is pretty hazy so far, clarification much needed )

Biochem High Points: Carb Metabolism

What enzyme shuts down gluconeogenesis?
fructose 1,6 phosphate
shuts down gluconeo when F6P or F26P concentrations rise

What two enzymes begin the process of breaking down glucose?
hexokinase in muscle and glucokinase in liver

What other sugar can hexokinase work on?
( self quiz, these are the ones I need to remember for boards )

Weird Corner Chair

I have this strange chair that is the corner out of a segmented sofa. It is supposed to be off white, but it is so old and dirty that it is more like gray mottled with brown. Last winter the roof leaked on it and the stains were the worst yet. I generally keep it covered with a blanket. Today I propped it up on the bannister of our tiny 2nd floor porch. I sprayed it with dilute dish soap, scrubbed the spots a little and hosed it off repeatedly. Then it started to rain. I thought "great, it will get rinsed off well". But then the rain set in as if it would never end. The chair might never dry left out on the porch. So I just wrangled the oversized ugly thing back into the foyer and set a fan on it. This chair only came with me to Oregon because my cat loved it. It is the thing that has told her we are "home" in the several moves we have made so far. I think this may be the end of the chair. It is a piece of garbage that I carted here with me from Arizona. I often think back on the stuff I loaded in a truck to bring here. Junk. But this chair has had its moments. It has been a good meditation chair. And it fits well in small nooks beside windows. I think I paid Suzanne (not this Suzanne but the prior one in my life) $10 for it. I can barely believe I paid ten bucks for this. But here it is. Funny how possessions can complicate our lives. I would have done well to get rid of it a long time ago, and the cat would have known some other way that we were home.

I keep thinking I should get rid of 90% of everything that I have.
Then I cram more stuff into the closet that I might use someday.