Last Year's Immunology Test
May. 13th, 2008 08:34 pm1. The following article was published this May in the Journal of
Clinical Immunology:
"Recurrence of autoreactive antigen-specific CD4+ T cells in
autoimmune diabetes after pancreas transplantation
CD4+ T cells specific for the diabetes-associated autoantigen GAD65
were analyzed using peripheral blood samples after pancreas
transplantation in subjects with T1D with clinical evidence of
recurrent autoimmune diabetes. Comparisons of TCR clonotypes by cDNA
sequencing revealed that identical T cells were present in the
circulation, separated by long time intervals, consistent with a
persistent memory response associated with recurrent autoimmunity."
Which cell and receptors are responsible for identifying the new
pancreas as foreign with the CD4 cells? What is alloreactivity?
Describe the cascade of events leading to the recurrence of
autoimmunity post-transplantation.
( first stab at answers )
Clinical Immunology:
"Recurrence of autoreactive antigen-specific CD4+ T cells in
autoimmune diabetes after pancreas transplantation
CD4+ T cells specific for the diabetes-associated autoantigen GAD65
were analyzed using peripheral blood samples after pancreas
transplantation in subjects with T1D with clinical evidence of
recurrent autoimmune diabetes. Comparisons of TCR clonotypes by cDNA
sequencing revealed that identical T cells were present in the
circulation, separated by long time intervals, consistent with a
persistent memory response associated with recurrent autoimmunity."
Which cell and receptors are responsible for identifying the new
pancreas as foreign with the CD4 cells? What is alloreactivity?
Describe the cascade of events leading to the recurrence of
autoimmunity post-transplantation.
( first stab at answers )